The L.A.U.N.C.H. (Linking & Amplifying User-Centered Networks through Connected Health) program will use human-centered design methodologies to identify the needs of cancer patients, caregivers and healthcare providers and use them to develop and deliver a connected solution to better manage cancer symptoms. The initiative is a collaboration between Amgen and the National Cancer Institute, the Federal Communications Commission Connect2Health Task Force, the University of Kentucky Markey Cancer Center and the University of California, San Diego Design Lab. The project will initially focus on underserved populations in rural, Appalachian Kentucky, and aims to develop a model for future symptom management projects.